[Effect of sarcolysin and asalin on the incorporation of thymidine-H3 in the DNA of sarcoma 45 and tissues of tumor-bearing rats].

Abstract

A comparison was made of the action of sarcolysin and asalin on the synthesis of DNA in sarcoma 45, the spleen, thymus, bone marrow and liver of tumour-bearing rats depending of the time of administration of the preparation. There was seen a direct relationship between the selectivity of sarcolysin and asalin action with a different bearer structure and the capacity of these perparations to depress DNA synthesis in the tumour and in normal tissues.

• Authors: V A Struchkov, V V Bergol'ts
• Journal: Biulleten' eksperimental'noi biologii i meditsiny (Biull Eksp Biol Med) Vol. 81 Issue 5 Pg. 589-91 (May 1976) ISSN: 0365-9615 [Print] Russia (Federation)
• Vernacular Title: Deĭstivie sarkolizina i asalina na vkliuchenie timidina-H3 v DNK sarkomy 45 i tkaneĭ krys-opukholenositeleĭ
• PMID: 947383 (Publication Type: English Abstract, Journal Article)

Chemical References

• DNA, Neoplasm
• DNA
• Melphalan
• Thymidine

Topics

• Animals
• Bone Marrow (drug effects, metabolism)
• DNA (biosynthesis)
• DNA, Neoplasm (biosynthesis)
• Liver (drug effects, metabolism)
• Male
• Melphalan (analogs & derivatives, pharmacology)
• Rats
• Sarcoma, Experimental (metabolism)
• Spleen (drug effects, metabolism)
• Thymidine (metabolism)
• Thymus Gland (drug effects, metabolism)
• Time Factors