[Superhigh-dosage chemotherapy with the transplantation of autologous hemopoietic precursor cells in patients with a prognostically unfavorable relapse and resistant course of lymphogranulomatosis].
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| Abstract |
Eighteen patients with relapsed or refractory Hodgkin's disease (HD) have been treated with high-dose chemotherapy (BEAM regimen) followed by autologous peripheral stem cells and/or bone marrow rescue. There were no treatment-related deaths. Overall response rate was 82%. With a median follow-up of 10 months (3-24 months) overall survival and freedom from progression were 100 and 94% (95% confidence interval 58-97%), respectively. The use of peripheral stem cells in addition to bone marrow resulted in a significant shortening of the time to engraftment (p < 0.01). The BEAM regimen is an effective conditioning schedule which is well tolerated.
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| Authors | V V Ptuskin, A L Uss, E A Demina, Iu V Chervonobab, N F Milanovich, N N Tupitsyn, V B Larionova, Z E Batan, N E Kondrat'eva, V A Zmachinskiĭ, L A Andreeva, V M Snegir', D M Mkheidze, K L Chimishkian |
| Journal | Terapevticheskii arkhiv (Ter Arkh) Vol. 69 Issue 10 Pg. 49-55 ( 1997) ISSN: 0040-3660 [Print] Russia (Federation) |
| Vernacular Title | Sverkhvysokodoznaia khimioterapiia s transplantatsieĭ autologichnykh kletok predshestvennikov gemopoéza u bol'nykh s prognosticheski neblagopriiatnym retsidivom i rezistentnym techeniem limfogranulematoza. |
| PMID | 9471790 (Publication Type: English Abstract, Journal Article) |
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