Abstract | OBJECTIVE: DESIGN: Case series. ANIMALS: 6 dogs with PDH that had a detectable pituitary mass on magnetic resonance images. PROCEDURE: Radiation was delivered in 11 fractions during a 3.5-week period for a total dose of 44 Gy. Clinical signs were evaluated, a urinalysis and ACTH stimulation test were performed, and urine cortisol-to- creatinine ratio and plasma endogenous ACTH concentration were measured before, immediately after, and 1, 3, 6, 9, and 12 months after radiotherapy. Magnetic resonance imaging was repeated 1 year after radiotherapy. RESULTS: Clinical signs of hyperadrenocorticism resolved in 3 dogs but recurred in 2 of the 3. Clinical condition of 2 dogs improved but did not return to normal. One dog did not improve. Results of ACTH stimulation tests and urine cortisol-to- creatinine ratios correlated with clinical signs. Plasma endogenous ACTH concentration transiently decreased in all 6 dogs. One year after radiotherapy, size of tumors was decreased by 25% in 2 dogs; in the other 4 dogs, tumors could no longer be detected. None of the dogs developed neurologic abnormalities. Adverse effects of radiotherapy were mild. CLINICAL IMPLICATIONS:
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Authors | M M Goossens, E C Feldman, A P Theon, P D Koblik |
Journal | Journal of the American Veterinary Medical Association
(J Am Vet Med Assoc)
Vol. 212
Issue 3
Pg. 374-6
(Feb 01 1998)
ISSN: 0003-1488 [Print] United States |
PMID | 9470046
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Adrenocortical Hyperfunction
(etiology, radiotherapy, veterinary)
- Animals
- Cobalt Radioisotopes
(therapeutic use)
- Dog Diseases
(etiology, radiotherapy)
- Dogs
- Female
- Magnetic Resonance Imaging
(veterinary)
- Male
- Pituitary Irradiation
(veterinary)
- Pituitary Neoplasms
(complications, diagnosis)
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