Abstract |
The possible preventive effect of Kampo medicine Hange-shashin-to (TJ-14) on chronic diarrheal symptoms induced by the administration of the anticancer agent irinotecan hydrochloride (CPT-11) was investigated in the rat. Repeated oral administrations of TJ-14 at 125 and 500 mg/kg significantly prevented the reduction in body weight and the onset of chronic diarrheal symptoms due to CPT-11 in a dose-dependent manner, even though it failed to show a definite effect on acute diarrheal symptoms. In addition, treatment with TJ-14 accelerated the healing of the intestinal tract injured by repeated dosing of CPT-11 and inhibited significantly the increase of colonic prostaglandin E2 ( PGE2) which is closely related to the onset of diarrhea. TJ-14 also improved colonic water absorption impaired by repeated dosing of CPT-11 in rats. These results demonstrate that TJ-14 is an effective medicine for the prevention and/or treatment of CPT-11-induced chronic diarrheal symptoms.
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Authors | Y Kase, T Hayakawa, M Aburada, Y Komatsu, T Kamataki |
Journal | Japanese journal of pharmacology
(Jpn J Pharmacol)
Vol. 75
Issue 4
Pg. 407-13
(Dec 1997)
ISSN: 0021-5198 [Print] Japan |
PMID | 9469647
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antineoplastic Agents, Phytogenic
- Drugs, Chinese Herbal
- Topoisomerase I Inhibitors
- hange-shashinto
- Water
- Irinotecan
- Dinoprostone
- Camptothecin
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Topics |
- Animals
- Antineoplastic Agents, Phytogenic
(toxicity)
- Camptothecin
(analogs & derivatives, toxicity)
- Colon
(drug effects, metabolism, pathology)
- Diarrhea
(chemically induced, prevention & control)
- Dinoprostone
(metabolism)
- Dose-Response Relationship, Drug
- Drugs, Chinese Herbal
(administration & dosage, pharmacology)
- Eating
(drug effects)
- Intestinal Absorption
(drug effects)
- Irinotecan
- Male
- Rats
- Rats, Wistar
- Topoisomerase I Inhibitors
- Water
(metabolism)
- Weight Gain
(drug effects)
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