HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Malignant pleural effusions treated with high dose intrapleural doxycycline: clinical efficacy and tolerance.

Abstract
Chronic malignant pleural effusion may be treated by instillating products in the pleural space to induce pleurodesis. We used intrapleural doxycycline at doses greater than 2000 mg in 16 malignant pleural effusion (14 patients). Patient survival ranged from 1 day to 19.5 months. Mean drainage duration was 7.5 days (range, 5-10 days). Pain (moderate n=7; severe n=2) was the most frequent side-effect with hypotension (moderate n=3; severe n=1). Five cases were not evaluable at one month because of death during the month following treatment (n=3) or during treatment (n=2). At one month follow-up, success was defined as no pleural effusion (n=5), partial response as minimal effusion (n=4) and we considered that treatment had failed if pleural drainage was necessary (n=2). Five patients died within one month and 5 had more than 3 months survival (4 without recurrence).
AuthorsA Prevost, P Nazeyrollas, D Milosevic, A Fernandez-Valoni
JournalOncology reports (Oncol Rep) 1998 Mar-Apr Vol. 5 Issue 2 Pg. 363-6 ISSN: 1021-335X [Print] Greece
PMID9468558 (Publication Type: Journal Article)
Chemical References
  • Anti-Bacterial Agents
  • Doxycycline
Topics
  • Adult
  • Aged
  • Anti-Bacterial Agents (administration & dosage, adverse effects)
  • Doxycycline (administration & dosage, adverse effects)
  • Female
  • Follow-Up Studies
  • Humans
  • Male
  • Middle Aged
  • Neoplasms (complications)
  • Pleural Effusion, Malignant (etiology, therapy)
  • Pleurodesis
  • Recurrence
  • Sclerotherapy
  • Survival Analysis
  • Treatment Outcome

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: