Abstract | OBJECTIVE: DESIGN: Case series. SETTING: Tertiary referral center. PATIENTS: Patients with confirmed Hantavirus infection, who developed severe cardiopulmonary failure in which conventional therapy was assessed as being unsuccessful. INTERVENTIONS: MEASUREMENTS AND MAIN RESULTS: Findings associated with a 100% mortality rate were a) cardiac index of <2.5 L/min/m2; b) serum lactate concentration of >4.0 mmol/L (normal range 0.0 to 2.2); c) pulseless electrical activity or ventricular fibrillation or ventricular tachycardia; and d) refractory shock despite fluid resuscitation, and vasoactive medications. From 1994 to 1996, seven patients were admitted with confirmed Hantavirus pulmonary syndrome and severe cardiopulmonary failure. Three of the seven patients had at least two of the four criteria for a 100% mortality rate listed above, and appeared to be failing optimal conventional therapy. These three patients received support with venoarterial ECMO. The first patient was placed on ECMO during cardiac arrest and died. The next two patients who received ECMO for Hantavirus pulmonary syndrome survived after relatively short, uncomplicated ECMO runs, and were discharged without complications. CONCLUSIONS:
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Authors | M R Crowley, R W Katz, R Kessler, S Q Simpson, H Levy, G W Hallin, J Cappon, J B Krahling, J Wernly |
Journal | Critical care medicine
(Crit Care Med)
Vol. 26
Issue 2
Pg. 409-14
(Feb 1998)
ISSN: 0090-3493 [Print] United States |
PMID | 9468181
(Publication Type: Case Reports, Journal Article, Review)
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Topics |
- Acute Disease
- Adult
- Combined Modality Therapy
- Critical Care
(methods)
- Extracorporeal Membrane Oxygenation
- Fatal Outcome
- Female
- Hantavirus Pulmonary Syndrome
(complications, diagnosis, pathology, therapy)
- Humans
- Male
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