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Potent anti-inflammatory activity of pheophytin a derived from edible green alga, Enteromorpha prolifera (Sujiao-nori).

Abstract
Recently, a chlorophyll-related compound, pheophytin a, has been identified from an edible green alga, Enteromorpha prolifera (Sujiao-nori in Japanese) as a potent suppressive substance against genotoxin-induced umu C gene expression in a tester bacteria (Okai and Higashi-Okai, 1997, J. Sci. Food Agricul. 71, 531-535). In the present study, anti-inflammatory effects of pheophytin a from Enteromorpha prolifera have been analyzed using in vitro and in vivo experiments. 1. Pheophytin a suppressed the production of superoxide anion (O2-) in mouse macrophages induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) using the cytochrome C reduction method. 2. Pheophytin a caused a suppressive effect against formyl-Met-Leu-Phe, (FMLP)-induced chemotaxis of human polymorphonuclear leukocytes (PMNs) in Boyden's chamber experiment. 3. Pheophytin a exhibited a significant suppression against TPA-induced inflammatory reaction such as edema formation in BALB/c mouse ear. These results suggest that pheophytin a from Enteromorpha prolifera has a potent anti-inflammatory activity.
AuthorsY Okai, K Higashi-Okai
JournalInternational journal of immunopharmacology (Int J Immunopharmacol) Vol. 19 Issue 6 Pg. 355-8 (Jun 1997) ISSN: 0192-0561 [Print] England
PMID9467755 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Anti-Inflammatory Agents
  • Pheophytins
  • Superoxides
  • N-Formylmethionine Leucyl-Phenylalanine
  • pheophytin a
  • Tetradecanoylphorbol Acetate
Topics
  • Animals
  • Anti-Inflammatory Agents (isolation & purification, pharmacology)
  • Chlorophyta (chemistry)
  • Edema (pathology)
  • Humans
  • In Vitro Techniques
  • Macrophages (drug effects, metabolism)
  • Mice
  • Mice, Inbred BALB C
  • N-Formylmethionine Leucyl-Phenylalanine (pharmacology)
  • Pheophytins (isolation & purification, pharmacology)
  • Superoxides (metabolism)
  • Tetradecanoylphorbol Acetate (pharmacology)

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