Abstract |
To evaluate delayed (long-term) effects of acute sarin poisoning on postural balance, nine male and nine female victims of the Tokyo Subway Sarin Poisoning in Japan ( sarin cases) were examined by computerized posturography 6-8 months after the poisoning. Their plasma cholinesterase activities (ChE) on the day of the poisoning (March 20, 1995) were 13-95 (mean 68.2) IU/l for females and 19-131 (mean 75.9) IU/l for males, which were not significantly different between the two sexes. In females, the postural sway of low frequency (0-1 Hz) in the anterior-posterior direction and area of sway with eyes open was significantly larger in the cases than in the controls. Romberg quotients for the low-frequency sway in the anterior-posterior direction for females and low-frequency sway and length of sway in the medio-lateral direction for males were significantly related to log ChE. It is suggested that a delayed effect on the vestibulo-cerebellar system was induced by acute sarin poisoning; females might be more sensitive than males.
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Authors | K Yokoyama, S Araki, K Murata, M Nishikitani, T Okumura, S Ishimatsu, N Takasu |
Journal | Journal of occupational and environmental medicine
(J Occup Environ Med)
Vol. 40
Issue 1
Pg. 17-21
(Jan 1998)
ISSN: 1076-2752 [Print] United States |
PMID | 9467116
(Publication Type: Clinical Trial, Controlled Clinical Trial, Journal Article)
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Chemical References |
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Topics |
- Adult
- Analysis of Variance
- Cerebellar Diseases
(chemically induced, diagnosis, epidemiology)
- Diagnostic Techniques, Neurological
- Female
- Follow-Up Studies
- Humans
- Male
- Middle Aged
- Motion Perception
(physiology)
- Movement
(physiology)
- Postural Balance
- Posture
- Prevalence
- Sarin
(poisoning)
- Sensation Disorders
(chemically induced)
- Sex Distribution
- Sex Factors
- Time Factors
- Tokyo
- Transportation
- Vestibular Diseases
(chemically induced, diagnosis, epidemiology)
- Violence
- Visual Acuity
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