Abstract | OBJECTIVE: Our purpose was to investigate the value of plasma glutathione S-transferase Alpha 1-1 measurements in the assessment of hepatocellular damage in hypertensive disorders of pregnancy. STUDY DESIGN: Patients were recruited at the Department of Obstetrics and Gynecology of the University Hospital, Nijmegen, The Netherlands. Five groups of patients were studied: normotensive pregnancy (n = 87), pregnancy-induced hypertension (n = 48), preeclampsia (n = 79), the syndrome of hemolysis, elevated liver enzymes, and low platelets (n = 39), and serially studied normotensive pregnancy (n = 21). Blood was collected for assessment of plasma glutathione S-transferase Alpha 1-1 levels and serum alanine aminotransferase activity. Levels in hypertensive pregnancies were compared with levels in normotensive pregnancy by the Mann-Whitney U test. Patients were categorized according as to whether their values are below (normal) or above (elevated) the upper normal reference level. The difference in relative magnitude of elevation between the two factors was determined by the Wilcoxon matched-pairs signed-rank test. RESULTS: CONCLUSION:
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Authors | M F Knapen, T P Mulder, J G Bisseling, R H Penders, W H Peters, E A Steegers |
Journal | American journal of obstetrics and gynecology
(Am J Obstet Gynecol)
Vol. 178
Issue 1 Pt 1
Pg. 161-5
(Jan 1998)
ISSN: 0002-9378 [Print] United States |
PMID | 9465822
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Biomarkers
- Glutathione Transferase
- Alanine Transaminase
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Topics |
- Adolescent
- Adult
- Alanine Transaminase
(blood)
- Biomarkers
(blood)
- Female
- Glutathione Transferase
(blood)
- HELLP Syndrome
(blood, diagnosis, etiology)
- Humans
- Hypertension
(blood)
- Liver
(pathology)
- Liver Diseases
(diagnosis, etiology, pathology)
- Longitudinal Studies
- Pre-Eclampsia
(blood, complications, pathology)
- Pregnancy
- Pregnancy Complications, Cardiovascular
(blood, pathology)
- Sensitivity and Specificity
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