[The use of immunotropic therapy in patients with systemic vasculitides].

Abstract

148 patients with systemic vasculitis (SV) were observed. In 90 of them "in vitro" we evaluated the action of immunotropic mediators (levamisol, timalin, human plasma immunoglobulin, placental polybiolin)--to evaluate the expression of lymphocyte antigens and oxide-renewal phagocyte activity. It was estimated, that the major sensitivity patients--do have lymphocytes to placental polybiolin. We studied the influence of this preparation in SV patients, and its effectivity was compared with glucocorticoids. It was estimated, that placental polybiolin has selective action upon T-lymphocytes subpopulations, improves antigens expression on operating variations of T-lymphocytes, stabilises humorally-regulatory protein figures. Its application effectivity makes 76.7% comparing to glucocorticoids (52.6%) in patients with light and middle degrees of systemic vasculitides hardness--individually sensitive to placental polybiolin.

• Authors: V V Chop'iak
• Journal: Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994) (Fiziol Zh (1994)) Vol. 43 Issue 5-6 Pg. 31-41 ( 1997) ISSN: 2522-9028 [Print] Ukraine
• Vernacular Title: Zastosuvannia imunotropnoï terapiï u khvorykh na systemni vaskulity.
• PMID: 9463006 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Adjuvants, Immunologic
• Glucocorticoids

Topics

• Adjuvants, Immunologic (therapeutic use)
• Adolescent
• Adult
• Antibody Formation (drug effects)
• Drug Evaluation
• Female
• Glucocorticoids (therapeutic use)
• Humans
• Immunity, Cellular (drug effects)
• Immunotherapy (methods)
• Male
• Phagocytosis (drug effects)
• Vasculitis (immunology, therapy)