I-123 iomazenil SPECT in patients with mental disorders.

Abstract

The purpose of this study is visual evaluation of the distribution of I-123 iomazenil in the brains of patients with various types of mental disorder and to examine whether chronic administration of a clinical dose of benzodiazepine (BZ) affects the binding of I-123 iomazenil to BZ receptors (BZR). The subjects were 10 patients with mental disorders (3 males and 7 females) with a mean age of 26.8 yrs (range 19-39 yrs). Four of 10 patients were administered BZ for over 3 months and the other six were free of BZ for over one month. The SPECT images were obtained at 5-25 min (early) and 170-190 min (delayed), after the bolus i.v. injection of 167 MBq of I-123 iomazenil, with a triple-head gamma camera. The images were visually evaluated and the washout ratios of each region were calculated. In visual analysis, abnormalities were recognized in 5 patients on the delaye SPECT. The abnormalities were recognized more frequently in the superior frontal lobe. The washout ratio was higher in the BZ (+) patient group than in the BZ (-) patient group. I-123 iomazenil is useful, because the SPECT image with I-123 iomazenil reflects the distribution of BZR on the brain and provides the different information from that obtained with perfusion SPECT, X-ray CT or MRI. The rapid washout of I-123 iomazenil from the brains of BZ (+) patients suggests that chronic administration of a clinical dose of BZ affects the binding of I-123 iomazenil to BZR.

• Authors: Y Nakabeppu, M Nakajo, T Naruo, Y Obo, S Nozoe, M Takigawa, S Tsuchimochi, A Tani, H Tanaka
• Journal: Annals of nuclear medicine (Ann Nucl Med) Vol. 11 Issue 4 Pg. 339-44 (Nov 1997) ISSN: 0914-7187 [Print] Japan
• PMID: 9460528 (Publication Type: Journal Article)

Chemical References

• Anti-Anxiety Agents
• Iodine Radioisotopes
• Radiopharmaceuticals
• Flumazenil
• iomazenil

Topics

• Adult
• Anti-Anxiety Agents (therapeutic use)
• Anxiety Disorders (diagnostic imaging, drug therapy, metabolism)
• Brain (diagnostic imaging, drug effects, metabolism)
• Female
• Flumazenil (analogs & derivatives, pharmacokinetics)
• Humans
• Iodine Radioisotopes (pharmacokinetics)
• Male
• Mental Disorders (diagnostic imaging, drug therapy, metabolism)
• Radiopharmaceuticals (pharmacokinetics)
• Tomography, Emission-Computed, Single-Photon (methods)