Oligosaccharide Le(a)-Le(x): a cell surface marker for carcinomas derived from embryonic endoderm.

Abstract

An immunohistochemical evaluation of Le(a)-Le(x) expression by adenocarcinomas of the biliary tree, pancreas, colon and stomach was undertaken as examples of epithelial tumors derived from embryonic endoderm. This complements previous studies showing that Lea-Lex was present on the cell surface of non-small cell lung carcinomas, some non-lung carcinomas, and is a prognostic marker for squamous cell lung carcinomas. All of the tumor specimen evaluated were positive and no expression of Le(a)-Le(x) was detected in derivatives of neural, connective or muscle tissues. These findings indicate that it could be informative to examine the biological significance of Le(a)-Le(x) not only in carcinogenesis but during embryogenesis, as well.

• Authors: P L Stranahan, J LaRoe, R McCombs, I Rahim, C W Kuhn, D E Pettijohn
• Journal: Oncology reports (Oncol Rep) 1998 Jan-Feb Vol. 5 Issue 1 Pg. 235-9 ISSN: 1021-335X [Print] Greece
• PMID: 9458328 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Biomarkers, Tumor
• Lewis Blood Group Antigens
• Lewis X Antigen
• Oligosaccharides
• lewis(a)-lewis(x)

Topics

• Adenocarcinoma (pathology, surgery)
• Biomarkers, Tumor (analysis)
• Carcinoma, Non-Small-Cell Lung (pathology)
• Colonic Neoplasms (pathology)
• Embryo, Mammalian
• Endoderm
• Gallbladder Neoplasms (pathology)
• Gastric Mucosa (pathology)
• Humans
• Immunohistochemistry (methods)
• Intestinal Mucosa (pathology)
• Lewis Blood Group Antigens
• Lewis X Antigen
• Lung Neoplasms (pathology)
• Metaplasia
• Neoplasms, Squamous Cell (pathology)
• Oligosaccharides (analysis)
• Pancreatic Neoplasms (pathology)
• Prognosis
• Stomach Neoplasms (pathology)