Abstract | BACKGROUND: METHODS: Lymph flow (QL; microliter/min) and lymph-to- plasma protein ratio (CL/CP) were monitored in groups of five to six dogs before and 4 hours after (1) a 5-second 100 degrees C or 90 degrees C foot paw scald; (2) IP3 (45 mg/kg intravenous bolus, then a 20 mg/kg/hr infusion) 30 minutes before or after 100 degrees C scald, or 30 minutes after 90 degrees C scald. Hind paw venous pressure was elevated and maintained by outflow restriction until reaching steady state QL and (CL/CP)min. Macromolecular reflection coefficient (1-CL/CP) was measured. Fluid filtration coefficient (Kf; ml/min/mm Hg/100 gm) was calculated. Relative paw weight gain (%) was measured. RESULTS: Compared with preburn values, scald uniformly produced significant increases in QL, CL/CP, and Kf, IP3 significantly (p < 0.02, ANOVA) reduced paw weight gain when given before, but not after, 100 degrees C burn (41% +/- 5% versus 18% +/- 7% preburn IP3 and 31% +/- 3% postburn IP3). Compared with 90 degrees C burn animals, postburn treatment significantly (p < 0.017) attenuated 4-hour increases in QL (550 +/- 87 versus 252 +/- 29 microliters/min), Kf (0.016 +/- 00 versus 0.007 +/- 00 microliter/min/mm/Hg/100 gm), and relative paw weight gain (28% +/- 3% versus 12% +/- 5%). CONCLUSIONS:
alpha-Trinositol given after a 90 degrees C scald blunted edema formation at the site of scald, likely through reduced transmembrane fluid flux.
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Authors | J J Ferrara, E L Kukuy, D A Gilman, E U Choe, E W Franklin, L M Flint |
Journal | Surgery
(Surgery)
Vol. 123
Issue 1
Pg. 36-45
(Jan 1998)
ISSN: 0039-6060 [Print] United States |
PMID | 9457221
(Publication Type: Journal Article)
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Chemical References |
- Anti-Inflammatory Agents, Non-Steroidal
- Inositol Phosphates
- atrinositol
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Topics |
- Analysis of Variance
- Animals
- Anti-Inflammatory Agents, Non-Steroidal
(blood, pharmacokinetics, therapeutic use)
- Blood Pressure
- Burns
(drug therapy, physiopathology)
- Capillaries
(drug effects, physiopathology)
- Dogs
- Edema
(etiology, prevention & control)
- Hindlimb
(blood supply)
- Inositol Phosphates
(blood, pharmacokinetics, therapeutic use)
- Lymph
(drug effects, physiology)
- Time Factors
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