The effect of lithium chloride on the activity of some psychotropic drugs.

Abstract

LiCl administered for 4 days enhances amphetamine-induced locomotor stimulation, increases amphetamine toxicity in aggregated mice but does not affect amphetamine stereotypy. Administered together with nialamide, LiCl increase locomotor activity of mice and rats. The administration of this compound together with reserpine reverses central effects of its action (hypothermia, decreased motility, enhancement of hexobarbital activity).

• Authors: M Wielosz
• Journal: Polish journal of pharmacology and pharmacy (Pol J Pharmacol Pharm) Vol. 28 Issue 2 Pg. 189-98 ( 1976) ISSN: 0301-0244 [Print] Poland
• PMID: 945563 (Publication Type: Journal Article)

Chemical References

• Amphetamines
• Psychotropic Drugs
• Reserpine
• Lithium
• Hexobarbital
• Nialamide

Topics

• Amphetamines (pharmacology, toxicity)
• Animals
• Body Temperature (drug effects)
• Drug Interactions
• Female
• Hexobarbital (pharmacology)
• Humans
• Lithium (pharmacology)
• Male
• Mice
• Motor Activity (drug effects)
• Nialamide (pharmacology)
• Psychotropic Drugs (pharmacology)
• Rats
• Reserpine (pharmacology)
• Stereotyped Behavior (drug effects)