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Follow-up of 18 patients with human immunodeficiency virus infection and chronic Chagas' disease, with reactivation of Chagas' disease causing cardiac disease in three patients.

Abstract
A series of 18 patients with chronic Chagas' disease and human immunodeficiency virus infection were followed up for 2 to 66 months (median, 15.5 months). Artificial xenodiagnosis was positive for 81.3% and natural xenodiagnosis was positive for 81.8% of patients for whom they were performed; 81.8% of 11 patients had medium- or high-level parasitemia. Reactivation of Chagas' disease--direct microscopic examination of blood revealing parasites and, clinically, patients presenting with cardiac disease--occurred in three patients (16.7%). Specific antitrypanosomal treatment with benznidazole was effective in reducing the level of parasitemia and improving the clinical condition in three of the four patients treated.
AuthorsA M Sartori, M A Shikanai-Yasuda, V Amato Neto, M H Lopes
JournalClinical infectious diseases : an official publication of the Infectious Diseases Society of America (Clin Infect Dis) Vol. 26 Issue 1 Pg. 177-9 (Jan 1998) ISSN: 1058-4838 [Print] United States
PMID9455528 (Publication Type: Journal Article)
Topics
  • Adult
  • Chagas Cardiomyopathy (etiology)
  • Chagas Disease (complications, diagnosis)
  • Female
  • Follow-Up Studies
  • HIV Infections (complications)
  • Humans
  • Male
  • Middle Aged
  • Parasitemia (diagnosis)

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