Interventional neuropediatrics: treatment of dystonic and spastic muscular hyperactivity with botulinum toxin A.
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| Abstract |
Therapeutic effect of botulinum toxin A was studied in a group of pediatric patients (n = 28) aged between 6 months and 18 years. The patients were diagnosed with cervical dystonia (n = 6), adductor spasm of the hip (n = 8), spastic drop foot (n = 7) and various other focal motor problems associated with spastic muscular hyperactivity (n = 7). The mean dose of botulinum toxin A (Dysport) used to inject into the affected muscle was 22 U/kg body weight. Reduced muscular hyperactivity with a significant increase in joint mobility was achieved for dystonic (p < 0.0001) as well as for spastic conditions in patients with adductor spasm (p < 0.0002). For these patients the improved joint mobility represented a significant benefit for both daily activities and nursing care. Local paresis and local hematoma were observed in 1/28 and 1/28 patients, respectively; 1/28 patients developed a secondary non-response. However, apart from these side effects, no other adverse reactions to botulinum toxin A treatment were recorded during the treatment and observation period (12-64 months). Our results suggest that botulinum toxin A represents an effective and safe therapeutic substance for the treatment of pediatric patients suffering of focal motor problems due to dystonic or spastic muscular hyperactivity.
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| Authors | F Heinen, J Wissel, A Philipsen, V Mall, J U Leititis, A Schenkel, R Stücker, R Korinthenberg |
| Journal | Neuropediatrics (Neuropediatrics) Vol. 28 Issue 6 Pg. 307-13 (Dec 1997) ISSN: 0174-304X [Print] Germany |
| PMID | 9453027 (Publication Type: Clinical Trial, Comparative Study, Journal Article) |
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