Satigrel, a new antiplatelet agent, inhibits platelet accumulation in prosthetic arterial grafts.

Abstract

BACKGROUND:

Early and late vascular obstruction are both related to platelet adhesion and aggregation in the grafts. We assessed the effect of satigrel, a new oral antiplatelet agent, on the accumulation of indium-labeled platelets in knitted Dacron grafts inserted proximal to the femoral artery.

METHODS:

Nine patients with arteriosclerosis obliterans receiving grafts were treated with satigrel, and 10 others were enrolled as untreated controls. Scintigraphy was performed in postoperative weeks 2 and 4, and the ratio of the scintillation count of the graft to that of the native artery was calculated to assess platelet accumulation.

RESULTS:

In both weeks 2 and 4, the ratio was significantly smaller in the satigrel group than in the control group for the whole graft, the proximal anastomosis, and the distal anastomosis.

CONCLUSIONS:

Satigrel significantly inhibited platelet accumulation in vascular grafts and thus may be useful for preventing postoperative graft occlusion.

• Authors: K Esato, Y Kubo, K Yasuda, H Shigematsu, T Iwai, S Ishimaru, H Uchida, K Ishii
• Journal: American journal of surgery (Am J Surg) Vol. 175 Issue 1 Pg. 56-60 (Jan 1998) ISSN: 0002-9610 [Print] United States
• PMID: 9445241 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Fatty Acids, Monounsaturated
• Indium Radioisotopes
• Platelet Aggregation Inhibitors
• Polyethylene Terephthalates
• Satigrel

Topics

• Aged
• Arteriosclerosis Obliterans (surgery)
• Blood Platelets
• Blood Vessel Prosthesis (adverse effects)
• Data Interpretation, Statistical
• Fatty Acids, Monounsaturated (administration & dosage, pharmacology)
• Humans
• Indium Radioisotopes
• Male
• Middle Aged
• Platelet Aggregation Inhibitors (administration & dosage, pharmacology)
• Polyethylene Terephthalates
• Prosthesis Failure
• Radionuclide Imaging
• Time Factors