Abstract |
To study potential ionic factors predisposing to vascular disease in hypertension, particularly among black subjects, we used a recently developed combined magnesium and calcium specific, ion selective electrode apparatus to measure extracellular ionized calcium (Ca-ion), ionized magnesium (Mg-ion), and Ca-ion/Mg-ion ratios in the serum of fasting, nonmedicated white and black normotensive (n = 61) and hypertensive (n = 23) subjects, studied consecutively in a tertiary referral center. Both race and blood pressure status had independent effects on the distribution of Mg-ion values. Although Mg-ion levels for the group as a whole were lower in hypertensive versus in normotensive subjects (0.571+/-0.012 v 0.601+/-0.005 mmol/L; P < .01), this was only true of white subjects (0.579+/-0.021 v 0.620+/-0.006 mmol/L; P = .0095). The lack of a significant difference in Mg-ion levels between black hypertensive versus normotensive subjects (0.553+/-0.012 v 0.577+/-0.007 mmol/L, P = NS) was attributable to the significantly lower Mg-ion levels present in normotensive blacks compared to those in normotensive white subjects (0.577+/-0.007 v 0.620+/-0.006 mmol/L, P = .0001). Resultant Ca-ion/Mg-ion ratios were elevated in all black subjects and in white hypertensive subjects. These data support the presence among hypertensives and among black subjects (independently of blood pressure) of a consistent depletion of circulating magnesium and of an imbalance of calcium and magnesium that may potentiate vascular disease among these subjects.
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Authors | L M Resnick, O Bardicef, B T Altura, M H Alderman, B M Altura |
Journal | American journal of hypertension
(Am J Hypertens)
Vol. 10
Issue 12 Pt 1
Pg. 1420-4
(Dec 1997)
ISSN: 0895-7061 [Print] United States |
PMID | 9443780
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Black People
- Blood Pressure
- Calcium
(blood)
- Female
- Humans
- Hypertension
(blood, ethnology)
- Magnesium
(blood)
- Male
- White People
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