High incidence of erythromycin-resistant Streptococcus pyogenes in Monza (North Italy) in untreated children with symptoms of acute pharyngo-tonsillitis: an epidemiological and molecular study.
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| Abstract |
A retrospective analysis of susceptibility data available for Group A streptococcal isolates collected between January 1990 and January 1996 at the Hospital Microbiology Laboratory of Monza (North Italy), showed a sharp rise in the erythromycin resistance rates during the last 3 years. Streptococcus pyogenes resistant to erythromycin accounted for approximately 1% of strains isolated between 1990 and 1992; the percentage then rose from 5% in 1993 to almost 39% in 1995. In January 1996, the resistance rates peaked to 81%. A prospective controlled study performed between March and May of 1996 to determine the percentage of erythromycin-resistant Group A streptococci isolated in Monza from untreated children with acute pharyngo-tonsillitis, gave further confirmation of a high rate of erythromycin resistance (47%) in this area. Molecular characterization by T-serotyping and pulse-field gel electrophoresis analysis of 25 erythromycin-resistant Group A streptococcal isolates, showed a relatively high degree of heterogeneity among these strains, demonstrating that the increased resistance is not caused by the spread of a single clone.
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| Authors | C E Cocuzza, R Mattina, A Mazzariol, G Orefici, R Rescaldani, A Primavera, S Bramati, G Masera, F Parizzi, G Cornaglia, R Fontana |
| Journal | Microbial drug resistance (Larchmont, N.Y.) (Microb Drug Resist) Vol. 3 Issue 4 Pg. 371-8 ( 1997) ISSN: 1076-6294 [Print] United States |
| PMID | 9442490 (Publication Type: Clinical Trial, Journal Article) |
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