Midazolam in treatment of various types of seizures in children.

Abstract

Midazolam is a recently developed water-soluble benzodiazepine that shares anxiolytic, muscle relaxant, hypnotic and anticonvulsant actions with other members of this class. There are limited studies that midazolam can be used successfully to treat seizures in adults and children. In this study, 0.2 mg/kg intramuscular (i.m.) midazolam was administered to 11 children (eight boys and three girls), aged 3 days to 4 years (mean age 1.8 +/- 1.4 years), with seizures of various types. In all but one child, seizures stopped in 15 s-5 min after injection. No side effects were observed. These results suggest that i.m. administration of midazolam may be useful in a variety of seizures during childhood, especially in case of intravenous (i.v.) line problem.

• Authors: C Yakinci, B Müngen, S Sahin, H Karabiber, Y Durmaz
• Journal: Brain & development (Brain Dev) Vol. 19 Issue 8 Pg. 571-2 (Dec 1997) ISSN: 0387-7604 [Print] Netherlands
• PMID: 9440805 (Publication Type: Clinical Trial, Journal Article)

Chemical References

• Anticonvulsants
• Midazolam

Topics

• Acute Disease
• Anticonvulsants (therapeutic use)
• Child, Preschool
• Female
• Humans
• Infant
• Infant, Newborn
• Injections, Intramuscular
• Male
• Midazolam (therapeutic use)
• Seizures (drug therapy)
• Treatment Outcome