Neurotrophins in cerebellar granule cell development and medulloblastoma.

Abstract

Medulloblastomas may be derived from granule cells of the developing cerebellum. Children with tumors expressing high levels of the neurotrophin-3 receptor, TrkC, have a more favorable outcome. During development, TrkC is expressed in the most mature granule cells. Favorable medulloblastomas may be derived from more highly differentiated granule cells.

• Authors: S L Pomeroy, M E Sutton, L C Goumnerova, R A Segal
• Journal: Journal of neuro-oncology (J Neurooncol) Vol. 35 Issue 3 Pg. 347-52 (Dec 1997) ISSN: 0167-594X [Print] United States
• PMID: 9440031 (Publication Type: Journal Article, Review)

Chemical References

• Nerve Growth Factors
• Proto-Oncogene Proteins
• Receptors, Nerve Growth Factor
• Receptor Protein-Tyrosine Kinases
• Receptor, trkA

Topics

• Animals
• Cerebellar Neoplasms (genetics, pathology, physiopathology)
• Cerebellum (cytology, growth & development)
• Cytoplasmic Granules (drug effects)
• Humans
• Medulloblastoma (genetics, pathology, physiopathology)
• Nerve Growth Factors (physiology)
• Proto-Oncogene Proteins (biosynthesis, genetics)
• Receptor Protein-Tyrosine Kinases (biosynthesis, genetics)
• Receptor, trkA
• Receptors, Nerve Growth Factor (biosynthesis, genetics)