Biphasic expression of CD4 in acute myelocytic leukemia (AML) cells: AML of monocyte origin and hematopoietic precursor cell origin.

Abstract

In 227 of 495 (45.9%) Japanese adult patients with acute myelocytic leukemia (AML), leukemic cells expressed CD4. Incidence of CD4 expression in each FAB subtype was as follows: M1 37.4%, M2 33.7%, M3 35.4%, M4 65.0%, and M5 78.3%. The typical expression pattern of myelomonocytic differentiation antigens and cytokine receptors in CD4+ AML was CD34lowCD33high CD11bhighGM-CSFRhigh. AML cases with 11q23 abnormalities and with inv(16) were frequently CD4-positive. These data collectively indicate that CD4 expression in AML cells is associated with monocytic characteristics. However, CD4+CD34high AML cases appear to have unique immature characteristics including low expression of myelomonocytic differentiation antigens (ie CD33 and CD11b), and accumulation of chromosome abnormalities (ie t(8;21) in CD4lowCD34high AML and chromosome 7 abnormalities in CD4highCD34high AML). We speculate that these leukemia subsets originate from CD4+ hematopoietic precursor cells, therefore then should be considered separately from most of the CD4+ AML as represented by CD34lowCD33high CD11bhighGM-CSFRhigh. Overall survival of patients with CD4+ AML in our series was worse than that of those with CD4 AML (P = 0.0202).

• Authors: H Miwa, M Mizutani, N Mahmud, M Yamaguchi, T Takahashi, M Shikami, H Shiku, I Tanaka, K Nakase, K Nasu, H Dohy, T Ueda, N Kamada, K Kita
• Journal: Leukemia (Leukemia) Vol. 12 Issue 1 Pg. 44-51 (Jan 1998) ISSN: 0887-6924 [Print] England
• PMID: 9436919 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antigens, CD
• CD4 Antigens
• HLA-DR Antigens

Topics

• Adult
• Antigens, CD (biosynthesis, blood)
• CD4 Antigens (biosynthesis, blood)
• Chromosome Aberrations
• Chromosome Deletion
• Chromosome Disorders
• Chromosome Inversion
• Chromosomes, Human, Pair 11
• Female
• HLA-DR Antigens (blood)
• Hematopoietic Stem Cells (immunology)
• Humans
• Immunophenotyping
• Karyotyping
• Leukemia, Myeloid, Acute (blood, genetics, immunology, mortality)
• Male
• Middle Aged
• Monocytes (immunology)
• Survival Rate
• Translocation, Genetic