Abstract |
Regulation of both the cell cycle and gene transcription is essential for orderly progression of cell growth and division. Recent results on the structures of two cyclins, cyclin A and cyclin H, and two transcription factor mediator proteins, TFIIB and the A pocket region of the retinoblastoma tumour suppressor protein (Rb), show that they share domains with a strikingly similar alpha-helical topology, despite remote sequence identity.
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Authors | M E Noble, J A Endicott, N R Brown, L N Johnson |
Journal | Trends in biochemical sciences
(Trends Biochem Sci)
Vol. 22
Issue 12
Pg. 482-7
(Dec 1997)
ISSN: 0968-0004 [Print] England |
PMID | 9433129
(Publication Type: Journal Article, Review)
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Chemical References |
- Cyclin A
- Cyclin H
- Cyclins
- Retinoblastoma Protein
- Transcription Factor TFIIB
- Transcription Factors
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Topics |
- Amino Acid Sequence
- Cell Cycle
- Cyclin A
(chemistry, metabolism)
- Cyclin H
- Cyclins
(chemistry, metabolism)
- Models, Molecular
- Molecular Sequence Data
- Protein Conformation
- Retinoblastoma Protein
(chemistry, metabolism)
- Sequence Homology, Amino Acid
- Transcription Factor TFIIB
- Transcription Factors
(chemistry, metabolism)
- Transcription, Genetic
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