Ranitidine bismuth citrate with clarithromycin for the eradication of Helicobacter pylori and for ulcer healing.

Abstract

BACKGROUND:

In a pilot study, ranitidine bismuth citrate (RBC; Pylorid, Tritec) in coprescription with clarithromycin achieved a Helicobacter pylori eradication rate (based on 13C urea breath test alone) of 83%. The aim of the current study was to validate this finding by using three diagnostic tests and a larger group of H. pylori-positive patients with active duodenal ulcer.

METHODS:

In a blinded study, 95 patients were given either 4 weeks of treatment with RBC, 400 mg bid, alone (RBC400, n = 31) or RBC, 400 mg bid or 800 mg bid, in coprescription with clarithromycin, 250 mg qid for 14 days, followed by 14 days of RBC, 400 mg bid, alone (RBC400 + CLAR and RBC800 + CLAR, respectively; n = 32 for each). Rates of ulcer healing at week 4 and of H. pylori eradication (assessed by antral and corpus urease tests and histology and by 13C urea breath test) at week 8 were compared, together with the incidence of adverse events.

RESULTS:

All three regimens were effective at duodenal ulcer healing and were tolerated well. The coprescription regimens gave significantly higher observed H. pylori eradication rates (82% and 74% for RBC400 + CLAR and RBC800 + CLAR) compared with RBC400 (0%; p < .001).

CONCLUSIONS:

RBC in dual therapy with clarithromycin provides excellent H. pylori eradication therapy and is an effective duodenal ulcer healing drug.

• Authors: R E Pounder, J W Wyeth, A E Duggan, R J Bailey, J A Louw, B Ohlin
• Journal: Helicobacter (Helicobacter) Vol. 2 Issue 3 Pg. 132-9 (Sep 1997) ISSN: 1083-4389 [Print] England
• PMID: 9432341 (Publication Type: Clinical Trial, Journal Article, Multicenter Study, Randomized Controlled Trial)

Chemical References

• Anti-Bacterial Agents
• Anti-Ulcer Agents
• Organometallic Compounds
• Ranitidine
• Clarithromycin
• bismuth tripotassium dicitrate

Topics

• Adult
• Aged
• Aged, 80 and over
• Anti-Bacterial Agents (administration & dosage)
• Anti-Ulcer Agents (administration & dosage)
• Clarithromycin (administration & dosage)
• Double-Blind Method
• Duodenal Ulcer (drug therapy, microbiology, pathology)
• Helicobacter Infections (drug therapy, pathology)
• Helicobacter pylori (drug effects)
• Humans
• Middle Aged
• Organometallic Compounds (administration & dosage)
• Ranitidine (administration & dosage)
• Treatment Outcome