Eicosanoids: role in gastrointestinal inflammation and cancer.

Abstract

This paper contains a brief review of the metabolism and physiological actions of eicosanoids, with a discussion of the potential clinical implications of disturbances in eicosanoid metabolism, particularly in NSAID-induced upper gastrointestinal damage and inflammatory bowel disease. There follows a summary of current evidence for the role of eicosanoids in the pathogenesis of colorectal neoplasia.

• Authors: G R Davies, D S Rampton
• Journal: European journal of gastroenterology & hepatology (Eur J Gastroenterol Hepatol) Vol. 9 Issue 11 Pg. 1033-44 (Nov 1997) ISSN: 0954-691X [Print] England
• PMID: 9431891 (Publication Type: Journal Article, Review)

Chemical References

• Anti-Inflammatory Agents, Non-Steroidal
• Cyclooxygenase Inhibitors
• Eicosanoids
• Prostaglandin Antagonists

Topics

• Animals
• Anti-Inflammatory Agents, Non-Steroidal (adverse effects, pharmacology)
• Colonic Neoplasms (prevention & control)
• Colonic Polyps (prevention & control)
• Colorectal Neoplasms (physiopathology)
• Cyclooxygenase Inhibitors (pharmacology)
• Eicosanoids (metabolism, physiology)
• Gastrointestinal Diseases (drug therapy, immunology, physiopathology)
• Humans
• Inflammation (physiopathology)
• Inflammatory Bowel Diseases (physiopathology)
• Peptic Ulcer (chemically induced, drug therapy, prevention & control)
• Prostaglandin Antagonists (pharmacology)