Abstract |
The effects of TTC-909, the isocarbacyclin methyl ester clinprost (CAS 88931-51-5), incorporated into lipid microspheres, on ischemia-induced decrease in norepinephrine (NE) contents in stroke-prone spontaneously hypertensive rats (SHR-SP) with an occluded middle cerebral artery (MCA) were examined. Occluding of MCA led to infarction limited to the cerebral cortex and also a severe decrease in NE contents in peripheral regions of the infarction. TTC-909 was injected immediately after MCA occlusion, and then daily for 6 consecutive days. As TTC-909 in a dose of 200 ng/kg significantly (p < 0.05) prevented decreases in NE contents, TTC-909 may have cytoprotective effects on neuronal damage related to ischemia in humans.
|
Authors | T Yae, H Araki, Y O-ogami, K Iwasaki, H Tanabe, M Fujiwara |
Journal | Arzneimittel-Forschung
(Arzneimittelforschung)
Vol. 47
Issue 11
Pg. 1200-3
(Nov 1997)
ISSN: 0004-4172 [Print] Germany |
PMID | 9428973
(Publication Type: Journal Article)
|
Chemical References |
- TTC 909
- Epoprostenol
- Norepinephrine
|
Topics |
- Animals
- Brain Chemistry
(drug effects)
- Cerebral Arteries
(physiology)
- Cerebral Infarction
(metabolism, pathology)
- Cerebrovascular Disorders
(genetics, physiopathology)
- Epoprostenol
(administration & dosage, analogs & derivatives, therapeutic use)
- Ischemic Attack, Transient
(drug therapy, metabolism, pathology)
- Male
- Microspheres
- Norepinephrine
(metabolism)
- Rats
- Rats, Inbred SHR
|