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Effects of the isocarbacyclin methyl ester clinprost incorporated into lipid microspheres, in focal ischemia of stroke-prone spontaneously hypertensive rats.

Abstract
The effects of TTC-909, the isocarbacyclin methyl ester clinprost (CAS 88931-51-5), incorporated into lipid microspheres, on ischemia-induced decrease in norepinephrine (NE) contents in stroke-prone spontaneously hypertensive rats (SHR-SP) with an occluded middle cerebral artery (MCA) were examined. Occluding of MCA led to infarction limited to the cerebral cortex and also a severe decrease in NE contents in peripheral regions of the infarction. TTC-909 was injected immediately after MCA occlusion, and then daily for 6 consecutive days. As TTC-909 in a dose of 200 ng/kg significantly (p < 0.05) prevented decreases in NE contents, TTC-909 may have cytoprotective effects on neuronal damage related to ischemia in humans.
AuthorsT Yae, H Araki, Y O-ogami, K Iwasaki, H Tanabe, M Fujiwara
JournalArzneimittel-Forschung (Arzneimittelforschung) Vol. 47 Issue 11 Pg. 1200-3 (Nov 1997) ISSN: 0004-4172 [Print] Germany
PMID9428973 (Publication Type: Journal Article)
Chemical References
  • TTC 909
  • Epoprostenol
  • Norepinephrine
Topics
  • Animals
  • Brain Chemistry (drug effects)
  • Cerebral Arteries (physiology)
  • Cerebral Infarction (metabolism, pathology)
  • Cerebrovascular Disorders (genetics, physiopathology)
  • Epoprostenol (administration & dosage, analogs & derivatives, therapeutic use)
  • Ischemic Attack, Transient (drug therapy, metabolism, pathology)
  • Male
  • Microspheres
  • Norepinephrine (metabolism)
  • Rats
  • Rats, Inbred SHR

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