Abstract |
A 123I-labeled tamoxifen derivative with a high affinity for the antiestrogen-binding site (AEBS) has been prepared. Biodistribution studies in rats showed a good linear correlation between the AEBS contents of tissue in fmol/g and the accumulated amount of radioactivity in percent dose per gram at 24 h.
|
Authors | P S Kruijer, R P Klok, C D van den Koedijk, M A Blankenstein, J H Voskuil, J F Verzeijlbergen, G J Ensing, J D Herscheid |
Journal | Nuclear medicine and biology
(Nucl Med Biol)
Vol. 24
Issue 8
Pg. 719-22
(Nov 1997)
ISSN: 0969-8051 [Print] United States |
PMID | 9428596
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Carcinogens
- Estrogen Antagonists
- Iodine Radioisotopes
- Radiopharmaceuticals
- Tamoxifen
- afimoxifene
- 9,10-Dimethyl-1,2-benzanthracene
|
Topics |
- 9,10-Dimethyl-1,2-benzanthracene
- Animals
- Binding Sites
- Carcinogens
- Estrogen Antagonists
(chemical synthesis, metabolism, pharmacokinetics)
- Female
- Iodine Radioisotopes
(chemistry)
- Mammary Neoplasms, Experimental
(chemically induced, metabolism)
- Radiopharmaceuticals
(chemical synthesis, pharmacokinetics)
- Rats
- Rats, Wistar
- Tamoxifen
(analogs & derivatives, chemical synthesis, pharmacokinetics)
- Tissue Distribution
|