Biodistribution of 123I-labeled 4-hydroxytamoxifen derivatives in rats with dimethylbenzanthracene-induced mammary carcinomas.

Abstract

A 123I-labeled tamoxifen derivative with a high affinity for the antiestrogen-binding site (AEBS) has been prepared. Biodistribution studies in rats showed a good linear correlation between the AEBS contents of tissue in fmol/g and the accumulated amount of radioactivity in percent dose per gram at 24 h.

• Authors: P S Kruijer, R P Klok, C D van den Koedijk, M A Blankenstein, J H Voskuil, J F Verzeijlbergen, G J Ensing, J D Herscheid
• Journal: Nuclear medicine and biology (Nucl Med Biol) Vol. 24 Issue 8 Pg. 719-22 (Nov 1997) ISSN: 0969-8051 [Print] United States
• PMID: 9428596 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Carcinogens
• Estrogen Antagonists
• Iodine Radioisotopes
• Radiopharmaceuticals
• Tamoxifen
• afimoxifene
• 9,10-Dimethyl-1,2-benzanthracene

Topics

• 9,10-Dimethyl-1,2-benzanthracene
• Animals
• Binding Sites
• Carcinogens
• Estrogen Antagonists (chemical synthesis, metabolism, pharmacokinetics)
• Female
• Iodine Radioisotopes (chemistry)
• Mammary Neoplasms, Experimental (chemically induced, metabolism)
• Radiopharmaceuticals (chemical synthesis, pharmacokinetics)
• Rats
• Rats, Wistar
• Tamoxifen (analogs & derivatives, chemical synthesis, pharmacokinetics)
• Tissue Distribution