Abstract | BACKGROUND:
Polyamine oxidase (PAO) is an enzyme involved in the interconversion pathway of polyamines, compounds required for cell proliferation and differentiation. As the role of PAO in tumor growth is unclear, and no data about PAO activity in human colorectal carcinoma are available, our aim was to investigate PAO activity and polyamine levels in this kind of tumor. METHODS:
Polyamine levels and PAO activity were detected in 30 neoplastic colorectal samples and surrounding mucosa by HPLC. RESULTS: Free and N1-acetylated polyamine levels were higher in the neoplastic tissue than surrounding mucosa of the same patient. On the contrary, PAO activity was significantly lower in the neoplastic tissue than surrounding mucosa. CONCLUSION:
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Authors | M Linsalata, A Cavallini, A Di Leo |
Journal | Anticancer research
(Anticancer Res)
1997 Sep-Oct
Vol. 17
Issue 5B
Pg. 3757-60
ISSN: 0250-7005 [Print] Greece |
PMID | 9427775
(Publication Type: Journal Article)
|
Chemical References |
- Neoplasm Proteins
- Polyamines
- Oxidoreductases Acting on CH-NH Group Donors
- polyamine oxidase
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Colorectal Neoplasms
(chemistry, enzymology)
- Female
- Humans
- Intestinal Mucosa
(chemistry, enzymology)
- Male
- Middle Aged
- Neoplasm Proteins
(analysis)
- Oxidoreductases Acting on CH-NH Group Donors
(analysis)
- Polyamines
(analysis)
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