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DNA repair: PARP - another guardian angel?

Abstract
Cell lines and mice defective in poly(ADP-ribose) polymerase (PARP) have elevated spontaneous genetic rearrangements and abnormal responses to stresses. These results may be explained by an altered response to damage induced by free radicals, and suggest that PARP limits genomic instability from such damage.
AuthorsP A Jeggo
JournalCurrent biology : CB (Curr Biol) Vol. 8 Issue 2 Pg. R49-51 (Jan 15 1998) ISSN: 0960-9822 [Print] England
PMID9427640 (Publication Type: Journal Article, Review)
Chemical References
  • Benzamides
  • Enzyme Inhibitors
  • Poly(ADP-ribose) Polymerase Inhibitors
  • 3-aminobenzamide
  • Poly(ADP-ribose) Polymerases
Topics
  • Animals
  • Benzamides (pharmacology)
  • DNA Repair
  • Enzyme Inhibitors (pharmacology)
  • Humans
  • Mice
  • Poly(ADP-ribose) Polymerase Inhibitors
  • Poly(ADP-ribose) Polymerases (genetics, metabolism)

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