Abstract |
Cell lines and mice defective in poly(ADP-ribose) polymerase (PARP) have elevated spontaneous genetic rearrangements and abnormal responses to stresses. These results may be explained by an altered response to damage induced by free radicals, and suggest that PARP limits genomic instability from such damage.
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Authors | P A Jeggo |
Journal | Current biology : CB
(Curr Biol)
Vol. 8
Issue 2
Pg. R49-51
(Jan 15 1998)
ISSN: 0960-9822 [Print] England |
PMID | 9427640
(Publication Type: Journal Article, Review)
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Chemical References |
- Benzamides
- Enzyme Inhibitors
- Poly(ADP-ribose) Polymerase Inhibitors
- 3-aminobenzamide
- Poly(ADP-ribose) Polymerases
|
Topics |
- Animals
- Benzamides
(pharmacology)
- DNA Repair
- Enzyme Inhibitors
(pharmacology)
- Humans
- Mice
- Poly(ADP-ribose) Polymerase Inhibitors
- Poly(ADP-ribose) Polymerases
(genetics, metabolism)
|