Therapeutic efficacy and bone mineral density response during and following a three-month re-treatment of endometriosis with nafarelin (Synarel).

Our goal was to determine the effects of a repeated course of the gonadotropin-releasing hormone agonist nafarelin on symptoms and signs of endometriosis and lumbar and distal radius bone mineral density.
Forty-five women previously treated for 6 months with nafarelin, who had recurrent symptoms and signs of endometriosis, received 400 mcg/day of nafarelin intranasally for 3 months. Efficacy was evaluated by changes in severity of symptoms and signs. Lumbar bone mineral density was measured by dual-energy x-ray absorptiometry and distal radius bone mineral density by single-photon absorptiometry. Bone mineral density was also measured in 10 control volunteers.
Repeated 3-month treatment significantly alleviated recurrent symptoms and signs of endometriosis. Lumbar bone mineral density decreased significantly by a mean of 2% at the end of treatment; this loss was restored within 3 to 6 months after treatment completion. No bone mineral density decline occurred in the radius. Bone mineral density changes in the control group were statistically insignificant.
A repeated 3-month course of nafarelin treatment significantly relieved recurrent endometriotic symptoms and signs without sustained loss of bone mineral density.
AuthorsG D Adamson, W L Heinrichs, M R Henzl, A A Yuzpe, C Bergquist, J J Jacobson, S Eriksson, L Kwei, S M Gilbert
JournalAmerican journal of obstetrics and gynecology (Am J Obstet Gynecol) Vol. 177 Issue 6 Pg. 1413-8 (Dec 1997) ISSN: 0002-9378 [Print] UNITED STATES
PMID9423744 (Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Hormones
  • Nafarelin
  • Estradiol
  • Adult
  • Bone Density
  • Endometriosis (drug therapy, metabolism)
  • Estradiol (blood)
  • Female
  • Hormones (adverse effects, therapeutic use)
  • Humans
  • Menstrual Cycle (blood)
  • Middle Aged
  • Nafarelin (adverse effects, therapeutic use)
  • Recurrence
  • Retreatment
  • Treatment Outcome

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