Symptomatic hepatic cysts: treatment with single-shot injection of minocycline hydrochloride.

Abstract

PURPOSE:

To assess the efficacy of percutaneous minocycline hydrochloride sclerotherapy in symptomatic hepatic cysts.

MATERIALS AND METHODS:

From November 1992 to June 1994, seven of eight consecutive adults with large symptomatic hepatic cysts (diameter, 55-130 mm) were treated with a single intracystic injection of minocycline hydrochloride in an ambulatory procedure. Five patients had a solitary cyst, and two had polycystic liver disease. The target cyst was punctured under ultrasound guidance and local anesthesia with a 22-gauge Chiba needle. Half of the cyst content was aspirated before injection of 100-500 mg of minocycline hydrochloride diluted in 5-25 mL of saline. The minocycline hydrochloride was left in the cyst at the end of the procedure.

RESULTS:

After a mean follow-up of 28 months (range, 24-42 months), all five patients with solitary cysts were asymptomatic and four had documented complete cyst regression; the two patients with multiple hepatic cysts showed only transient clinical improvement.

CONCLUSION:

Single-shot injection of minocycline hydrochloride is an effective treatment for symptomatic solitary hepatic cysts but is less effective in polycystic liver disease.

• Authors: C Cellier, C A Cuenod, P Deslandes, J Auroux, B Landi, N Siauve, J P Barbier, G Frija
• Journal: Radiology (Radiology) Vol. 206 Issue 1 Pg. 205-9 (Jan 1998) ISSN: 0033-8419 [Print] United States
• PMID: 9423674 (Publication Type: Journal Article)

Chemical References

• Anti-Bacterial Agents
• Minocycline

Topics

• Anti-Bacterial Agents (administration & dosage, therapeutic use)
• Cysts (diagnostic imaging, therapy)
• Drainage
• Female
• Follow-Up Studies
• Humans
• Injections, Intralesional
• Liver Diseases (diagnostic imaging, therapy)
• Male
• Middle Aged
• Minocycline (administration & dosage, therapeutic use)
• Prospective Studies
• Radiography
• Sclerotherapy
• Time Factors
• Ultrasonography