[Disseminated intravascular coagulation in a case of adult onset Still's disease].

Abstract

We report a 82-year-old woman with adult onset Still's disease (AOSD), who presented with high fever, skin rash, swollen axillary lymph nodes, accelerated erythrocyte sedimentation rate, leukocytosis, abnormal liver function tests, hypoalbuminemia, negative antinuclear antibody and rheumatoid factor, and lack of renal involvement. Disseminated intravascular coagulation (DIC) was also diagnosed on admission. An antipyretic relieved high fever and DIC soon improved. Three years later, AOSD relapsed accompanied by hypercoagulation and hyperfibrinolysis. The patient developed subdural hematoma and DIC due to a brain contusion. High titers of serum soluble adhesion molecules and soluble thrombomodulin were noted on the first episode of DIC. These findings indicated that endothelial cells were damaged in AOSD complicated by DIC.

• Authors: I Sanada, F Kawano, A Tsukamoto, T Kiyokawa, T Shido, S Koga
• Journal: [Rinsho ketsueki] The Japanese journal of clinical hematology (Rinsho Ketsueki) Vol. 38 Issue 11 Pg. 1194-8 (Nov 1997) ISSN: 0485-1439 [Print] Japan
• PMID: 9423337 (Publication Type: Case Reports, English Abstract, Journal Article)

Topics

• Aged
• Aged, 80 and over
• Disseminated Intravascular Coagulation (etiology)
• Female
• Humans
• Still's Disease, Adult-Onset (complications)