Abstract | RATIONALE AND OBJECTIVES: METHODS: "Equine" magnetoferritin was administered intravenously at 5 mg protein and 1.4 mg Fe/kg in nude rats carrying subcutaneous xenografted human small-cell lung carcinoma with and without preinjection of 100 mg/kg equine apoferritin. Blood clearance, in vivo biodistribution, and proton relaxation enhancement were assessed by variable field relaxometry, immunohistochemistry, and magnetic resonance (MR) imaging at 1.5 T. RESULTS:
Magnetoferritin clearance from blood followed biexponential kinetics, with a short initial half-life of 1.4-1.7 min. A second, longer component lasted for several hours. Histochemical staining, MR imaging, and ex vivo relaxometry revealed rapid uptake of magnetoferritin in the liver, spleen, and lymph nodes. There was no difference in biodistribution after apoferritin preinjection. CONCLUSION:
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Authors | J W Bulte, T Douglas, S Mann, J Vymazal, P G Laughlin, J A Frank |
Journal | Academic radiology
(Acad Radiol)
Vol. 2
Issue 10
Pg. 871-8
(Oct 1995)
ISSN: 1076-6332 [Print] United States |
PMID | 9419653
(Publication Type: Journal Article)
|
Chemical References |
- Contrast Media
- Oxides
- magnetoferritin
- Apoferritins
- Iron
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Topics |
- Animals
- Apoferritins
(analogs & derivatives, blood, pharmacokinetics)
- Carcinoma, Small Cell
(diagnosis, metabolism)
- Contrast Media
- Female
- Iron
(blood, pharmacokinetics)
- Liver
(metabolism)
- Lung Neoplasms
(diagnosis, metabolism)
- Lymph Nodes
(metabolism)
- Magnetic Resonance Imaging
- Oxides
(blood, pharmacokinetics)
- Rats
- Rats, Nude
- Spleen
(metabolism)
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