Abstract | RATIONALE AND OBJECTIVES: METHODS: RESULTS: After injection of iomeprol-containing liposomes at a dose of 70 mg of liposome-entrapped iodine per kilogram of body weight, the normal liver parenchyma showed a contrast enhancement, in Hounsfield units, of more than 60% over the control value before bolus. Liver tumors with no or few Kupffer cells were not enhanced and appeared as dark areas within the normal parenchyma. Tumors and pretumoral lesions devoid of Kupffer cells, as small as 3 mm in diameter, could be distinguished using this non-invasive method. CONCLUSION: CT liver scanning after injection of iomeprol-containing liposomes appears to be promising method for detecting liver tumors and focal liver lesions.
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Authors | X Fouillet, H Tournier, H Khan, S Sabitha, S Burkhardt, F Terrier, M Schneider |
Journal | Academic radiology
(Acad Radiol)
Vol. 2
Issue 7
Pg. 576-83
(Jul 1995)
ISSN: 1076-6332 [Print] United States |
PMID | 9419607
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Contrast Media
- Drug Carriers
- Liposomes
- iomeprol
- Iopamidol
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Topics |
- Animals
- Carcinoma, Hepatocellular
(diagnostic imaging, pathology)
- Contrast Media
- Disease Models, Animal
- Dose-Response Relationship, Drug
- Drug Carriers
- Female
- Injections, Intravenous
- Iopamidol
(analogs & derivatives)
- Kupffer Cells
(pathology)
- Liposomes
- Liver Neoplasms, Experimental
(diagnostic imaging, pathology)
- Male
- Radiographic Image Enhancement
(methods)
- Rats
- Rats, Sprague-Dawley
- Tomography, X-Ray Computed
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