Abstract | BACKGROUND: METHODS: RESULTS: Microinjection of fentanyl bilaterally into the locus ceruleus increased the root mean square and decreased the mean power frequency values of electromyographic signals. The efficacy of fentanyl to elicit muscular rigidity in this manner was significantly reduced by previous intrathecal administration of either 6-cyano-7-nitroquinoxaline-2,3-dione ( CNQX), (+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10- imine maleate (MK-801), D-(-)-2-amino-5-phosphonovaleric acid (AP5), or (+/-)-3-(2-carboxypiperazin-4-yl)-propyl-1- phosphonic acid ( CPP). Intrathecal administration of kainic acid or NMDA also resulted in significant electromyographic activation. CONCLUSIONS:
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Authors | M J Fu, L Y Tsen, T Y Lee, P W Lui, S H Chan |
Journal | Anesthesiology
(Anesthesiology)
Vol. 87
Issue 6
Pg. 1450-9
(Dec 1997)
ISSN: 0003-3022 [Print] United States |
PMID | 9416730
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Analgesics, Opioid
- Receptors, Glutamate
- Receptors, N-Methyl-D-Aspartate
- Tyrosine 3-Monooxygenase
- Fentanyl
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Topics |
- Analgesics, Opioid
(pharmacology)
- Animals
- Electromyography
(drug effects)
- Fentanyl
(pharmacology)
- Locus Coeruleus
(drug effects, pathology)
- Male
- Muscle Rigidity
(chemically induced, enzymology, physiopathology)
- Rats
- Rats, Sprague-Dawley
- Receptors, Glutamate
(drug effects, metabolism)
- Receptors, N-Methyl-D-Aspartate
(agonists, antagonists & inhibitors)
- Synaptic Transmission
(drug effects)
- Tyrosine 3-Monooxygenase
(metabolism)
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