Tumor specific contrast enhancement study of Mn-metalloporphyrin (ATN-10)--comparison of rat brain tumor model, cytotoxic and vasogenic edema models.

Abstract

ATN-10, Mn-metalloporphyrin, has been developed as a tumor selective contrast agent for magnetic resonance (MR) imaging. To investigate the tumor specificity of ATN-10, we produced three experimental in vivo models; rat bran tumor (9L glioma) model, vasogenic (cold injury) and cytotoxic brain edema (24-hour MCA occlusion) models. The time course of contrast enhancement was compared after intravenous injection of ATN-10 or Gd-DTPA, measuring the signal intensity of the region of interest. After ATN-10 administration, the 9L glioma model showed early (5 min) and delayed (24 hr-) peak enhancement whereas the cold injury model showed only early enhancement and the 24-hour MCA occlusion model did not show significant enhancement. After Gd-DTPA administration, all three models showed similar pattern of only early enhancement. As a contrast agent for MR imaging, ATN-10 showed different behavior than Gd-DTPA in demonstrating the blood-brain barrier disruption and moreover ATN-10 showed selective enhancement in experimental brain tumors.

• Authors: H Fujimori, A Matsumura, T Yamamoto, Y Shibata, T Yoshizawa, K Nakagawa, Y Yoshii, T Nose, I Sakata, S Nakajima
• Journal: Acta neurochirurgica. Supplement (Acta Neurochir Suppl) Vol. 70 Pg. 167-9 ( 1997) ISSN: 0065-1419 [Print] Austria
• PMID: 9416311 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Contrast Media
• Deuteroporphyrins
• Indium Radioisotopes
• ATN 10
• Gadolinium DTPA

Topics

• Animals
• Blood-Brain Barrier (physiology)
• Brain Edema (diagnosis)
• Brain Neoplasms (diagnosis)
• Cell Survival (physiology)
• Cold Temperature
• Contrast Media
• Deuteroporphyrins
• Disease Models, Animal
• Gadolinium DTPA
• Glioma (diagnosis)
• Indium Radioisotopes
• Magnetic Resonance Imaging (methods)
• Male
• Rats
• Rats, Inbred F344