Abstract | BACKGROUND: METHODS:
Myocardial infarction was induced in 8 dogs by ligation of the left anterior descending coronary artery, 4 of which were reperfused after 3 hr Gd- Mesoporphyrin (0.05 mmol/kg) was injected intravenously 210 min after the onset of ischemia (n = 6) or after 24 hr in 2 dogs with non-reperfused infarctions. MRI was performed 10 hr after administration of Gd- Mesoporphyrin. In vivo MRI consisted of EKG-triggered, respiratory gated T1-weighted spin echo and segmented turboFLASH long and short axis measurements. Post-mortem, a spin echo short axis measurement was repeated. Infarct size was determined planimetrically by TTC staining of left ventricular slices. RESULTS: In all instances, there was a very close qualitative agreement between the MRI and TTC defined myocardial infarction. Quantitatively, the linear regression from post-mortem MRI to TTC determined infarct size yielded a result very close to the line of identity (regression coefficient: 0.980 +/- 0.026, p < 0.000001, adjusted R2 = 0.964). CONCLUSION:
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Authors | P Herijgers, S K Laycock, Y Ni, G Marchal, J Bogaert, H Bosmans, C Petré, W Flameng |
Journal | International journal of cardiac imaging
(Int J Card Imaging)
Vol. 13
Issue 6
Pg. 499-507
(Dec 1997)
ISSN: 0167-9899 [Print] Netherlands |
PMID | 9415852
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Coloring Agents
- Metalloporphyrins
- Tetrazolium Salts
- triphenyltetrazolium
- Gadolinium
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Topics |
- Animals
- Coloring Agents
- Dogs
- Female
- Gadolinium
- Humans
- Image Enhancement
(methods)
- Magnetic Resonance Imaging
(methods)
- Male
- Metalloporphyrins
- Myocardial Infarction
(diagnosis)
- Tetrazolium Salts
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