The effect of castanospermine on the metastatic properties of prostate cancer cells.

Abstract

BACKGROUND:

Most deaths from prostate cancer result from the metastatic spread of the disease. Castanospermine has been shown to inhibit tumor growth and metastasis in mouse and rat models. We hypothesized that castanospermine might inhibit metastasis in the Dunning model of rat prostate adenocarcinoma by interfering with the metastatic properties of tumor cells.

MATERIALS AND METHODS:

We examined the cytotoxicity of castanospermine toward the metastatic MAT-LyLu and nonmetastatic AT. 1 cell lines and its effects on cell motility and adhesion to endothelial cells. We assessed castanospermine's effects on in vivo metastasis in Copenhagen rats.

RESULTS:

Castanospermine was not cytotoxic toward the MAT-LyLu and AT. 1 cell lines at concentrations through 10 micrograms/mL, nor did it significantly affect cell motility, adhesion to endothelial cells, or in vivo metastasis.

CONCLUSIONS:

Within the Dunning model, castanospermine did not appear to significantly affect cell characteristics related to metastatic potential.

• Authors: C S Yee, E D Schwab, J E Lehr, M Quigley, K J Pienta
• Journal: Anticancer research (Anticancer Res) 1997 Sep-Oct Vol. 17 Issue 5A Pg. 3659-63 ISSN: 0250-7005 [Print] Greece
• PMID: 9413219 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Indolizines
• castanospermine

Topics

• Adenocarcinoma (pathology)
• Animals
• Cell Survival (drug effects)
• Indolizines (pharmacology)
• Male
• Neoplasm Invasiveness
• Neoplasm Metastasis
• Phagocytosis (drug effects)
• Prostatic Neoplasms (pathology)
• Rats
• Tumor Cells, Cultured