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Multidrug resistance-associated protein gene expression and drug sensitivity in human lung cancer cells.

Abstract
Multidrug resistance-associated protein (MRP) mRNA expression and drug sensitivity in lung cancer cells were examined, and the effects of verapamil, a modulating agent for MRP, on drug sensitivity were also tested. Nine cell lines expressed various levels of MRP gene expression but not the MDR1 gene. The levels were higher in non-small cell carcinoma cells (NSCLC) than in small cell carcinoma cells (SCLC). Clear correlations between the MRP gene level and the sensitivity to etoposide (VP-16) and doxorubicin (Dox) were observed except for one cell line which highly expressed DNA topoisomerase II. Positive correlations between the MRP gene levels in three cell lines and the modulation effects of verapamil in VP-16, Dox, and vincristine were observed. The present results indicate that MRP probably confers intrinsic multidrug resistance in NSCLC rather than in SCLC.
AuthorsF Narasaki, M Oka, M Fukuda, K Ikeda, K Terashi, H Takatani, T Nakamura, H Soda, S Kohno
JournalAnticancer research (Anticancer Res) 1997 Sep-Oct Vol. 17 Issue 5A Pg. 3493-7 ISSN: 0250-7005 [Print] Greece
PMID9413193 (Publication Type: Journal Article)
Chemical References
  • ATP-Binding Cassette Transporters
  • Multidrug Resistance-Associated Proteins
  • RNA, Messenger
  • Vincristine
  • Etoposide
  • Doxorubicin
  • Verapamil
  • Cisplatin
Topics
  • ATP-Binding Cassette Transporters (genetics)
  • Cisplatin (pharmacology)
  • Doxorubicin (pharmacology)
  • Drug Resistance, Multiple
  • Etoposide (pharmacology)
  • Gene Expression Regulation, Neoplastic (genetics)
  • Genes, MDR
  • Humans
  • Lung Neoplasms
  • Multidrug Resistance-Associated Proteins
  • RNA, Messenger (genetics)
  • Tumor Cells, Cultured (drug effects)
  • Verapamil (pharmacology)
  • Vincristine (pharmacology)

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