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Bipolar affective disorder associated with Klinefelter's syndrome--a case report.

Abstract
Several cytogenetic surveys and literature reviews have suggested a possible association between Klinefelter's syndrome and bipolar illness. We describe a manic patient with Klinefelter's syndrome who was treated successfully with lithium. Our patient represents the 32nd reported case of bipolar disorder in an individual with a known chromosomal abnormality, the 15th with Klinefelter's syndrome, and the 11th with a karyotype of 47XXY.
AuthorsM Bekaroglu, C Soylu, N Soylu, M Bilici
JournalThe Israel journal of psychiatry and related sciences (Isr J Psychiatry Relat Sci) Vol. 34 Issue 4 Pg. 308-10 ( 1997) ISSN: 0333-7308 [Print] Israel
PMID9409088 (Publication Type: Case Reports, Journal Article)
Topics
  • Adult
  • Bipolar Disorder (genetics)
  • Genetic Linkage (genetics)
  • Humans
  • Karyotyping
  • Klinefelter Syndrome (genetics)
  • Male
  • X Chromosome

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