Abstract |
A new, non-invasive method for measuring reserpine-induced tremor in rodents is described here. The test procedure is based on the piezo-electric principle and was evaluated using the tremorogenic compound reserpine and the stereotypies-inducing drug apomorphine. Whereas for reserpine an orderly and dose-related increase in activity was observed, no such effect was detected with apomorphine. In order to further evaluate the test procedure, studies on the antagonism of reserpine-induced tremor were also performed. Results from these studies indicated that the DA-agonist lisuride, but not the S2-antagonist ritanserin, were able to antagonize the reserpine-induced tremor in a dose-related manner.
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Authors | T F Meert, J Rombouts, J Voeten, F Naranji, G Clincke |
Journal | Acta neurobiologiae experimentalis
(Acta Neurobiol Exp (Wars))
Vol. 57
Issue 1
Pg. 75-81
( 1997)
ISSN: 0065-1400 [Print] Poland |
PMID | 9407694
(Publication Type: Technical Report)
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Chemical References |
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Topics |
- Animals
- Electric Conductivity
- Electronics
(instrumentation)
- Female
- Rats
- Rats, Wistar
- Reserpine
(pharmacology)
- Sympatholytics
(pharmacology)
- Tremor
(chemically induced, diagnosis)
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