A simple, non-invasive method for the measurement of reserpine-induced tremor in rats.

Abstract

A new, non-invasive method for measuring reserpine-induced tremor in rodents is described here. The test procedure is based on the piezo-electric principle and was evaluated using the tremorogenic compound reserpine and the stereotypies-inducing drug apomorphine. Whereas for reserpine an orderly and dose-related increase in activity was observed, no such effect was detected with apomorphine. In order to further evaluate the test procedure, studies on the antagonism of reserpine-induced tremor were also performed. Results from these studies indicated that the DA-agonist lisuride, but not the S2-antagonist ritanserin, were able to antagonize the reserpine-induced tremor in a dose-related manner.

• Authors: T F Meert, J Rombouts, J Voeten, F Naranji, G Clincke
• Journal: Acta neurobiologiae experimentalis (Acta Neurobiol Exp (Wars)) Vol. 57 Issue 1 Pg. 75-81 ( 1997) ISSN: 0065-1400 [Print] Poland
• PMID: 9407694 (Publication Type: Technical Report)

Chemical References

• Sympatholytics
• Reserpine

Topics

• Animals
• Electric Conductivity
• Electronics (instrumentation)
• Female
• Rats
• Rats, Wistar
• Reserpine (pharmacology)
• Sympatholytics (pharmacology)
• Tremor (chemically induced, diagnosis)