Assessment of possible protective roles of selenium, zinc, and cis-stilbene oxide against acute T-2 toxin poisoning: a preliminary report.

Abstract

The efficacy of two free radical scavengers, selenium and zinc, and a microsomal epoxide hydrolase-inducing agent, cis-stilbene oxide on the acute toxicity of T-2 toxin, a potent cytotoxic trichothecene, was investigated. Mice were pretreated daily for 3 consecutive days with either zinc sulfate (4.4 mg/kg, intraperitoneally [i.p.]), sodium selenite (1, 2, and 3 mg/kg i.p.) or cis-stilbene oxide (50 mg/kg i.p.). A full 24-hr after the final dosing with these agents, mice were given T-2 toxin (2, 2.5, or 3 mg/kg i.p.). The acute lethal toxicity of T-2 toxin (2.5 mg/kg) was reduced by administration of only sodium selenite (3 mg/kg) and cis-stilbene oxide (50 mg/kg). No significant effect on weight gain was observed.

• Authors: H Yazdanpanah, F Roshanzamir, B Shafaghi, M Faizi, M Elhami, H R Rasekh
• Journal: Natural toxins (Nat Toxins) Vol. 5 Issue 4 Pg. 133-5 ( 1997) ISSN: 1056-9014 [Print] United States
• PMID: 9407554 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Free Radical Scavengers
• Stilbenes
• Epoxide Hydrolases
• Selenium
• T-2 Toxin
• Zinc
• stilbene oxide

Topics

• Animals
• Dose-Response Relationship, Drug
• Epoxide Hydrolases (metabolism)
• Free Radical Scavengers (therapeutic use)
• Male
• Mice
• Mice, Inbred Strains
• Microsomes (enzymology)
• Poisoning (prevention & control)
• Selenium (therapeutic use)
• Stilbenes (therapeutic use)
• T-2 Toxin (toxicity)
• Zinc (therapeutic use)