Abstract |
Fine-needle aspiration (FNA) of superficial and deep seated lesions has been used with high sensitivity and specificity in the diagnosis of neoplastic and non-neoplastic entities. However, studies of FNA in post-transplant patients are virtually absent. Six hundred and seventy-four allograft recipients (cardiac 288, renal 250, lung 131 and heart-lung 5) were reviewed. A total of 30 (25 heart, 4 lungs and 1 renal transplant) patients underwent an FNA procedure. There were 26 males and 4 females. Ages ranged from 18-63 yr (mean 48 yr). The most common entity aspirated was post-transplant lymphoproliferative disorder (PTLD) in 12 cases, followed by inflammatory lesions in 10 cases, malignant epithelial neoplasms in 3 cases, and 1 case each of malignant mesenchymal tumor, pulmonary infarction, hamartoma of liver, fatty changes of liver, and a benign vascular lesion. Surgical or autopsy tissue was available in 19 cases (63.3%). There was an agreement between tissue diagnosis and FNA material in 18 cases (94.7%). One (5.2%) false negative case was recorded. This was a liver aspirate showing benign liver elements, which a surgical biopsy proved to be a bile duct hamartoma. No false positive cases were recorded. FNA is a highly sensitive and specific diagnostic tool in the management of post-transplant patients.
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Authors | M T Siddiqui, V B Reddy, M J Castelli, P Gattuso |
Journal | Diagnostic cytopathology
(Diagn Cytopathol)
Vol. 17
Issue 6
Pg. 429-35
(Dec 1997)
ISSN: 8755-1039 [Print] United States |
PMID | 9407203
(Publication Type: Journal Article)
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Topics |
- Adolescent
- Adult
- Biopsy, Needle
(methods)
- Cholestasis
(diagnosis, etiology)
- Cytodiagnosis
- Female
- Humans
- Inflammation
(diagnosis, etiology)
- Lymphoproliferative Disorders
(diagnosis, etiology)
- Male
- Middle Aged
- Neoplasms, Glandular and Epithelial
(diagnosis, etiology)
- Organ Transplantation
(adverse effects, pathology)
- Pulmonary Embolism
(diagnosis, etiology)
- Sensitivity and Specificity
- Soft Tissue Infections
(diagnosis, etiology)
- Transplantation, Homologous
(adverse effects)
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