Abstract | RATIONALE AND OBJECTIVES: The authors intended to confirm previous findings that paramagnetic porphyrins are avid only for intratumoral nonviable tissues, but not for viable tumor cells, and to test the hypothesis that necrosis, regardless of location and origin, can be visualized by metalloporphyrin enhanced magnetic resonance imaging (MRI). METHODS: RESULTS: Both Gd-DTPA and the four metalloporphyrins initially caused a similar nonspecific negative contrast enhancement in the necrosis. However, a strong and persisting positive enhancement ( necrosis-to-normal contrast ratio ranging from 1.5 to 2.0) developed only with metalloporphyrins in all types of necrosis. In liver and kidney, Gd and Mn concentrations at 24 hours were comparable in necrotic and normal tissues. In muscle, the concentrations were more than eight times higher in necrotic than in normal tissue. CONCLUSIONS:
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Authors | Y Ni, C Petré, Y Miao, J Yu, E Cresens, P Adriaens, H Bosmans, W Semmler, A L Baert, G Marchal |
Journal | Investigative radiology
(Invest Radiol)
Vol. 32
Issue 12
Pg. 770-9
(Dec 1997)
ISSN: 0020-9996 [Print] United States |
PMID | 9406018
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Contrast Media
- Metalloporphyrins
- Gadolinium DTPA
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Topics |
- Animals
- Contrast Media
(pharmacokinetics)
- Disease Models, Animal
- Gadolinium DTPA
(administration & dosage, pharmacokinetics)
- Image Enhancement
(methods)
- Infarction
(diagnosis, metabolism)
- Infusions, Intravenous
- Kidney
(blood supply, metabolism, pathology)
- Liver
(blood supply, metabolism, pathology)
- Magnetic Resonance Imaging
- Metalloporphyrins
(administration & dosage, pharmacokinetics)
- Muscle, Skeletal
(blood supply, metabolism, pathology)
- Necrosis
- Rats
- Rats, Wistar
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