Abstract | OBJECTIVES: Assess hemodynamic effect of Conn's syndrome in order to better prepare patients for surgical resection of their adenoma. PATIENTS AND METHODS: RESULTS:
Hypertension was associated with a significant increase in stroke volume and a non-significant increase in cardiac index. Blood pressure normalized after sprironolactone and after surgery in parallel with a significant decrease in blood volume. DISCUSSION: These hemodynamic disorders in Conn's disease patients suggest that the increase in stroke volume is a consequence of increased venous return and more likely, in myocardium contractility or a combination of both. CONCLUSION:
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Authors | G Amah, J Blacher, X Girerd, A Kheder, H Ben Maiz, M Safar |
Journal | Presse medicale (Paris, France : 1983)
(Presse Med)
Vol. 26
Issue 29
Pg. 1372-7
(Oct 04 1997)
ISSN: 0755-4982 [Print] France |
Vernacular Title | Syndrome de Conn. Etude de l'hémodynamique cardio-vasculaire systémique après traitement médical par spironolactone et après traitement chirurgical. |
PMID | 9404344
(Publication Type: Clinical Trial, English Abstract, Journal Article, Multicenter Study)
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Chemical References |
- Mineralocorticoid Receptor Antagonists
- Spironolactone
- Sodium
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Topics |
- Adolescent
- Adult
- Female
- Hemodynamics
(drug effects)
- Humans
- Hyperaldosteronism
(drug therapy, physiopathology, surgery)
- Hypertension
(physiopathology)
- Male
- Middle Aged
- Mineralocorticoid Receptor Antagonists
(pharmacology, therapeutic use)
- Postoperative Period
- Sodium
(physiology)
- Spironolactone
(pharmacology, therapeutic use)
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