Abstract | OBJECTIVES: STUDY DESIGN: Medical records of 394 patients with TS who were followed up at Thomas Jefferson Hospital and Children's Hospital of Pittsburgh were reviewed for documentation of TS phenotype, constitutional cytogenetics, and history of neuroblastoma or related tumors. Informative cases were reviewed for tumor pathology, primary site, disease stage, associated symptoms, treatment, and outcome. RESULTS: CONCLUSIONS: These data strongly suggest that girls with TS are predisposed to the development of neuroblastoma and related tumors. Because these tumors are often of limited stage and may be underdiagnosed, screening of urine of patients with TS for elevated catecholamine metabolite levels may strengthen this association.
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Authors | J Blatt, A F Olshan, P A Lee, J L Ross |
Journal | The Journal of pediatrics
(J Pediatr)
Vol. 131
Issue 5
Pg. 666-70
(Nov 1997)
ISSN: 0022-3476 [Print] United States |
PMID | 9403643
(Publication Type: Case Reports, Journal Article)
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Topics |
- Adolescent
- Child
- Child, Preschool
- Chromosome Aberrations
(genetics)
- Chromosome Deletion
- Chromosome Disorders
- Female
- Follow-Up Studies
- Genetic Linkage
(genetics)
- Humans
- Infant
- Infant, Newborn
- Karyotyping
- Neuroblastoma
(complications, genetics)
- Turner Syndrome
(complications, genetics)
- X Chromosome
(genetics)
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