BE-32030 A, B, C, D and E, new antitumor substances produced by Nocardia sp. A32030.

Abstract

New antitumor substances, designated BE-32030A, B, C, D and E, were isolated from the culture broth of Nocardia sp. A32030. The active principles were extracted from the mycelium by methanol and purified by Sephadex LH-20 and reversed-phase column chromatographies and finally by reversed-phase HPLC. BE-32030A, B, C, D and E inhibited the growth of P388 murine leukemia, DLD-1 human colon cancer, PC-13 human lung cancer and MKN-45 human stomach cancer cell lines.

• Authors: M Tsukamoto, K Murooka, S Nakajima, S Abe, H Suzuki, K Hirano, H Kondo, K Kojiri, H Suda
• Journal: The Journal of antibiotics (J Antibiot (Tokyo)) Vol. 50 Issue 10 Pg. 815-21 (Oct 1997) ISSN: 0021-8820 [Print] England
• PMID: 9402985 (Publication Type: Journal Article)

Chemical References

• Antibiotics, Antineoplastic
• Azepines
• BE 32030A
• BE 32030B
• BE 32030C
• BE 32030D
• BE 32030E
• Oxazoles

Topics

• Animals
• Antibiotics, Antineoplastic (chemistry, metabolism, pharmacology)
• Azepines (chemistry, metabolism, pharmacology)
• Drug Screening Assays, Antitumor
• Fermentation
• Humans
• Mice
• Molecular Structure
• Nocardia (chemistry, metabolism)
• Oxazoles (chemistry, metabolism, pharmacology)