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Pepsinogen polymorphism in the Indian population and its association with duodenal ulcer.

Abstract
To date, there have been few studies on pepsinogen polymorphism. The present study examines the polymorphism of pepsinogen by PAGE in 155 duodenal ulcer cases and 92 control subjects. The Indian population presents a higher frequency of the B phenotype (associated with absence of the pg 5 fraction) and the C haplotype compared to other populations. Heterozygotes, in particular AC phenotypic individuals, are found to be associated significantly with the disease compared to control subjects. All the genes of the multigene complex controlling pepsinogen polymorphism seem to be interacting, thereby leading to such an association. Thus, studies at the gene level may be helpful in explaining the genetic etiology and heterogeneity of duodenal ulcer disease.
AuthorsA Venkateshwari, A Vidyasagar, R Prasad, B Pratap, N Pratibha
JournalHuman genetics (Hum Genet) Vol. 101 Issue 2 Pg. 201-4 (Dec 1997) ISSN: 0340-6717 [Print] GERMANY
PMID9402969 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Pepsinogens
Topics
  • Adult
  • Aged
  • Duodenal Ulcer (blood, etiology, genetics)
  • Gene Frequency
  • Helicobacter Infections (complications, diagnosis)
  • Humans
  • India (epidemiology)
  • Middle Aged
  • Pepsinogens (blood, genetics)
  • Phenotype
  • Polymorphism, Genetic

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