Abstract |
The effect of repeated doses of TNF-alpha on the histological picture of the pulmonary tissue was analyzed in the present study. Special attention was paid to the lung rebuilding processes. TNF-alpha was applied intraperitoneally for two weeks in a dose of 10 micrograms/0.5 ml PBS/24h. Morphological analysis of the pulmonary tissue was performed after 1 and 28 days following the last TNF-alpha dose. The study revealed focal pulmonary tissue rebuilding with emphysema-like changes twenty eight days following termination of TNF-alpha administration. The rebuilding processes included interalveolar septal atrophy, collagen accumulation and damage-repair changes in type II alveolar epithelial cells. It has been demonstrated that apart from the protease- antiprotease hypothesis of the lung emphysema, the inflammatory-repair hypothesis should be considered. Both hypotheses are complementary to each other and interpret the emphysema-like changes as complications of various pathological conditions of the pulmonary tissue.
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Authors | M Sulkowska, S Sulkowski, S Terlikowski, H F Nowak |
Journal | Polish journal of pathology : official journal of the Polish Society of Pathologists
(Pol J Pathol)
Vol. 48
Issue 3
Pg. 179-88
( 1997)
ISSN: 1233-9687 [Print] Poland |
PMID | 9401411
(Publication Type: Journal Article)
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Chemical References |
- Tumor Necrosis Factor-alpha
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Topics |
- Animals
- Emphysema
(drug therapy, pathology)
- Epithelial Cells
(drug effects)
- Male
- Pulmonary Alveoli
(cytology, drug effects)
- Rats
- Rats, Wistar
- Tumor Necrosis Factor-alpha
(therapeutic use)
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