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Tumor necrosis factor-alpha induces emphysema-like pulmonary tissue rebuilding. Changes in type II alveolar epithelial cells.

Abstract
The effect of repeated doses of TNF-alpha on the histological picture of the pulmonary tissue was analyzed in the present study. Special attention was paid to the lung rebuilding processes. TNF-alpha was applied intraperitoneally for two weeks in a dose of 10 micrograms/0.5 ml PBS/24h. Morphological analysis of the pulmonary tissue was performed after 1 and 28 days following the last TNF-alpha dose. The study revealed focal pulmonary tissue rebuilding with emphysema-like changes twenty eight days following termination of TNF-alpha administration. The rebuilding processes included interalveolar septal atrophy, collagen accumulation and damage-repair changes in type II alveolar epithelial cells. It has been demonstrated that apart from the protease-antiprotease hypothesis of the lung emphysema, the inflammatory-repair hypothesis should be considered. Both hypotheses are complementary to each other and interpret the emphysema-like changes as complications of various pathological conditions of the pulmonary tissue.
AuthorsM Sulkowska, S Sulkowski, S Terlikowski, H F Nowak
JournalPolish journal of pathology : official journal of the Polish Society of Pathologists (Pol J Pathol) Vol. 48 Issue 3 Pg. 179-88 ( 1997) ISSN: 1233-9687 [Print] Poland
PMID9401411 (Publication Type: Journal Article)
Chemical References
  • Tumor Necrosis Factor-alpha
Topics
  • Animals
  • Emphysema (drug therapy, pathology)
  • Epithelial Cells (drug effects)
  • Male
  • Pulmonary Alveoli (cytology, drug effects)
  • Rats
  • Rats, Wistar
  • Tumor Necrosis Factor-alpha (therapeutic use)

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