Tetramethoxydibenzoquinolizinium salts. Preparation and antileukemic activity of some positional and structural isomers of coralyne.

Abstract

Some positional and structural isomers of coralyne were prepared and evaluated in the P388 lymphocytic leukemia system for their inhibitory activity. The levels of antileukemic activity of coralyne, neocoralyne, isocoralyne, and stracoralyne were comparable, thus implying that two sets of the N-O-O triangular pharmacophore in a condensed isoquinoline molecule are preferable and the angle between these two sets has little influence on antileukemic activity. The importance of the environment around the C5-C6 region of the dibenzo[a,g]quinolizine ring to antileukemic activity was demonstrated by the activity differences between coralyne and allocoralyne.

• Authors: R K Zee-Cheng, C C Cheng
• Journal: Journal of medicinal chemistry (J Med Chem) Vol. 19 Issue 7 Pg. 882-6 (Jul 1976) ISSN: 0022-2623 [Print] United States
• PMID: 940108 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Antineoplastic Agents
• Berberine Alkaloids
• Quaternary Ammonium Compounds
• Quinolizines
• coralyne

Topics

• Animals
• Antineoplastic Agents (chemical synthesis, therapeutic use)
• Berberine Alkaloids (chemical synthesis)
• Isomerism
• Leukemia, Experimental (drug therapy)
• Mice
• Quaternary Ammonium Compounds (chemical synthesis, therapeutic use)
• Quinolizines (chemical synthesis, therapeutic use)
• Structure-Activity Relationship